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- Title
Unfused amnion and chorion after 14 weeks of gestation: associated fetal structural and chromosomal abnormalities.
- Authors
Ulm, B.; Ulm, M. R.; Bernaschek, G.
- Abstract
Objective To assess possible associations between delayed chorioamniotic fusion after the end of the first trimester and fetal structural and/or chromosomal abnormalities. Design We prospectively studied 492 fetuses from high-risk pregnancies between 14 and 18 weeks of gestation by transabdominal ultrasonography. Of these, 60 (12%) had unfused amnion and chorion. Results No additional abnormalities were detected in 28/60 fetuses (47%). Karyotyping was performed in 27/28 cases, and one fetus had trisomy 13 (4%). Ten of 24 fetuses (42%) of this group attending a second mid-trimester scan after 18 weeks of gestation had abnormal sonographic findings not noted at the initial scan. Thirty-two of 60 (53%) fetuses had additional abnormalities at the initial scan: cystic hygroma (n = 12), increased nuchal translucency (n = 10) and other abnormalities (n = 10). Karyo-typing revealed aneuploidy in 13 of 28 fetuses (46%) tested: trisomy 21 (n = 5), Turner's syndrome (n = 3), trisomy 18 (n = 3) and trisomy 13 (n = 2). Additional fetal abnormalities were detected only at the second scan after 18 weeks of gestation in three of eight fetuses (38%). Conclusions These preliminary data suggest that the sonographic finding of unfused amnion and chorion after 14 weeks of gestation may be associated with fetal structural and/or chromosomal abnormalities.
- Subjects
AMNION; CHORION; HIGH-risk pregnancy; FETAL development
- Publication
Ultrasound in Obstetrics & Gynecology, 1999, Vol 13, Issue 6, p392
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1046/j.1469-0705.1999.13060392.x