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- Title
Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-β<sub>25-35</sub> Peptide in CA1 Pyramidal Neurons of Neonatal Rat Hippocampal Slice.
- Authors
Li, Li; Tsai, Hao-Jan; Li, Lin; Wang, Xue-Mei
- Abstract
Overload of intracellular calcium caused by amyloid-β peptide has been implicated in the pathogenesis of neuronal damage in Alzheimer's disease. Voltage-gated calcium channels (VGCCs) provide one of the major sources of Ca2+ entry into cells. Here, we investigated whether icariin had effect on the changes of calcium currents induced by Aβ25-35 in hippocampal pyramidal neurons. Using whole-cell patch-clamp, we showed that Aβ25-35 enhanced the inward Ba2+ and Ca2+ currents. The currents were partially inhibited by Ni2+ and completely suppressed by Cd2+, indicating that Aβ25-35 disrupts intracellular calcium homeostasis via the modulation of both L- and T-type channels. Furthermore, icariin nearly complete suppressed the abnormal inward calcium currents induced by Aβ25-35 in a dose-dependant manner. Our findings suggest that the potential neuroprotective effect of icariin on Aβ25-35-induced neurotoxicity via the balance intracelluar calcium homeostasis.
- Subjects
FLAVONOIDS; CALCIUM channels; ALTERNATIVE treatment for Alzheimer's disease; NEUROPROTECTIVE agents; NEUROTOXICOLOGY; PHYSIOLOGY
- Publication
American Journal of Chinese Medicine, 2010, Vol 38, Issue 1, p113
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X10007701