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- Title
Comparison of two subsets of Chinese patients with retroperitoneal fibrosis in terms of IgG4 immunohistochemical staining.
- Authors
Liao, Simin; Zhang, Xueguang; Zhu, Fei; Wang, Yiwen; Zhu, Jian; Zhang, Jianglin; Huang, Feng
- Abstract
Objective To identify clinical and pathological differences between IgG4-related retroperitoneal fibrosis (IgG4-RPF) and idiopathic RPF (iRPF) in a Chinese population. Method Clinical and pathological data of 50 RPF patients from 2006 to 2016 were retrospectively analysed. The presence of at least one characteristic histopathological feature, >30 IgG4+ plasma cells per high power field, and an IgG4+/IgG+ plasma cells ratio cutoff of >40% were used to define IgG4-RPF. Results Patients with IgG4-RPF were significantly more likely to have pain (94.1 vs 68.8%, P = 0.048), elevated serum IgE concentration (166.1 vs 40.2 IU/ml, P = 0.029) and tissue eosinophilia (47.1 vs 12.5%, P = 0.018), compared with patients with iRPF. In the IgG4-RPF subgroup, patients with tissue eosinophilia demonstrated higher levels of CRP (4.3 vs 1.9 mg/dl, P = 0.027) and ESR (62.1 vs 22.8 mm/h, P = 0.001). Among the 50 patients with RPF, the average number of tissue IgG4+ plasma cells was positively correlated with the number of tissue eosinophils (r = 0.37, P = 0.009). Moreover, serum IgG4 concentration and serum IgE concentration showed positive correlation (r = 0.834, P = 0.000). Conclusion The distinct serological and histopathological features of Chinese patients with IgG4-RPF were elevated serum IgE concentration and tissue eosinophilia, which potentially can aid and support the diagnosis. As serum IgG4 concentration may be normal in patients with IgG4-RPF, serum IgE may represent a useful serological marker in distinguishing IgG4-RPF from iRPF.
- Subjects
CHINA; BIOMARKERS; BLOOD sedimentation; C-reactive protein; CHINESE people; EOSINOPHILIA; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; RETROPERITONEUM; SERODIAGNOSIS; STAINS &; staining (Microscopy); FIBROSIS; PAIN measurement; RETROSPECTIVE studies; DIAGNOSIS
- Publication
Rheumatology, 2019, Vol 58, Issue 3, p455
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/key324