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- Title
Side effects of influenza vaccination in healthy older people: a randomised single-blind placebo-controlled trial.
- Authors
Allsup, Stephen James; Gosney, Margot; Regan, Martyn; Haycox, Alan; Fear, Simon; Johnstone, Fiona C. W.; Allsup, S J; Gosney, M; Regan, M; Haycox, A; Fear, S; Johnstone, F C
- Abstract
<bold>Objectives: </bold>To investigate the frequency of side effects following influenza vaccination in healthy participants aged 65-74 years.<bold>Materials and Methods: </bold>A single-blind randomised placebo-controlled trial was performed in general practices in central Liverpool on 729 healthy individuals (341 females and 388 males) aged 65-74 (median age 68.9) years, of whom 552 received influenza vaccine and 177 received placebo. The main outcome measures were analysed from adverse reactions reported by the subjects on a postal questionnaire 3 days after vaccination.<bold>Results: </bold>724 (99.3%) questionnaires were returned. 62 (11.3%) participants who received influenza vaccination complained of local symptoms compared with 9 (5.1%) participants who received placebo (difference 6.2%; 95% CI 1.3 to 10.0%; p = 0.02). 192 (35.1%) individuals who received influenza vaccine complained of one or more systemic side effects compared with 75 (42.4%) who received placebo (difference -7.3%; 95% CI -15.6 to 0.9%; p = 0.10).<bold>Conclusion: </bold>Healthy people belonging to this age group can be reassured that, when compared with placebo, influenza vaccination causes few, if any, systemic side effects and only a low incidence of local side effects.
- Subjects
VACCINATION complications; INFLUENZA vaccines; INFLUENZA; HEALTH of older people; DRUG side effects; INFLUENZA prevention; AGE distribution; COMPARATIVE studies; CONFIDENCE intervals; COST effectiveness; DEMOGRAPHY; IMMUNIZATION; RESEARCH methodology; MEDICAL cooperation; PROBABILITY theory; REFERENCE values; RESEARCH; RISK assessment; STATISTICAL sampling; SEX distribution; EVALUATION research; RANDOMIZED controlled trials; DISEASE incidence; BLIND experiment; ECONOMICS
- Publication
Gerontology, 2001, Vol 47, Issue 6, p311
- ISSN
0304-324X
- Publication type
journal article
- DOI
10.1159/000052820