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- Title
Analysis of the Wound-Healing Activity of Sodium Carboxymethyl Cellulose (1%) with Metronidazole (0.25%) and Chlorhexidine (0.025%) in the Ultraviolet Erythema Model in Guinea Pigs as Compared with Levomekol Gel.
- Authors
Filatova, A. V.
- Abstract
The plasticization of jelly obtained by structuring a sodium carboxymethyl cellulose solution with a complex salt of aluminum and citric acid was studied. Jelly base containing 1% sodium carboxymethyl cellulose and 15% glycerol had a dynamic viscosity of 4.7 Pa∙s, retained its shape, and was well lubricated. Stability studies of the gel base after storage for 24 months at 25 ± 10°C showed that the appearance, color, and smell did not change. The base remained uniform and stable. The pH value did not exceed the established limits. The thermal stability of gel samples was visually assessed in a thermostat at 40 – 42°C for 24 h. Phase separation was not observed in any of the gel samples. Gel samples met the requirements of bacteriological analysis. The inclusion of antibacterial (metronidazole, 0.25%) and antiseptic drugs (chlorhexidine, 0.025%) in the developed base statistically significantly increased the wound healing activity to 92 ± 4.5% (p < 0.05) as compared to the drug Levomekol (78 ± 3.8%, p < 0.05) in the ultraviolet erythema model.
- Subjects
SODIUM carboxymethyl cellulose; GUINEA pigs; CHLORHEXIDINE; METRONIDAZOLE; DYNAMIC viscosity; CITRIC acid
- Publication
Pharmaceutical Chemistry Journal, 2023, Vol 57, Issue 9, p1499
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-023-03016-7