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- Title
Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride.
- Authors
Krylov, V.; Moiseev, S.; Kutin, A.; Sakhno, N.; Gunar, O.; Yashkir, V.; Merkulov, V.
- Abstract
An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.
- Subjects
AMANTADINE; ANTIBACTERIAL agents; HYDROCHLORIC acid; DRUG synthesis; RIMANTADINE; CHEMICAL structure; THERAPEUTICS
- Publication
Pharmaceutical Chemistry Journal, 2016, Vol 49, Issue 12, p821
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-016-1379-0