Found: 14

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  • Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

    Published in:
    Nature, 2011, v. 476, n. 7360, p. 346, doi. 10.1038/nature10350
    By:
    • Possemato, Richard;
    • Marks, Kevin M.;
    • Shaul, Yoav D.;
    • Pacold, Michael E.;
    • Kim, Dohoon;
    • Birsoy, K?vanç;
    • Sethumadhavan, Shalini;
    • Woo, Hin-Koon;
    • Jang, Hyun G.;
    • Jha, Abhishek K.;
    • Chen, Walter W.;
    • Barrett, Francesca G.;
    • Stransky, Nicolas;
    • Tsun, Zhi-Yang;
    • Cowley, Glenn S.;
    • Barretina, Jordi;
    • Kalaany, Nada Y.;
    • Hsu, Peggy P.;
    • Ottina, Kathleen;
    • Chan, Albert M.
    Publication type:
    Article

  • CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

    Published in:
    2018
    By:
    • Liying Chen;
    • Alexe, Gabriela;
    • Dharia, Neekesh V.;
    • Ross, Linda;
    • Iniguez, Amanda Balboni;
    • Conway, Amy Saur;
    • Emily Jue Wang;
    • Veschi, Veronica;
    • Lam, Norris;
    • Jun Qi;
    • Gustafson, W. Clay;
    • Nasholm, Nicole;
    • Vazquez, Francisca;
    • Weir, Barbara A.;
    • Cowley, Glenn S.;
    • Ali, Levi D.;
    • Pantel, Sasha;
    • Guozhi Jiang;
    • Harrington, William F.;
    • Yenarae Lee
    Publication type:
    journal article

  • The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.

    Published in:
    Nature Immunology, 2015, v. 16, n. 5, p. 495, doi. 10.1038/ni.3143
    By:
    • Ramirez-Ortiz, Zaida G;
    • Prasad, Amit;
    • Griffith, Jason W;
    • Pendergraft, William F;
    • Cowley, Glenn S;
    • Root, David E;
    • Tai, Melissa;
    • Luster, Andrew D;
    • El Khoury, Joseph;
    • Hacohen, Nir;
    • Means, Terry K
    Publication type:
    Article

  • Integrated genetic and pharmacologic interrogation of rare cancers.

    Published in:
    Nature Communications, 2016, v. 7, n. 6, p. 11987, doi. 10.1038/ncomms11987
    By:
    • Hong, Andrew L.;
    • Tseng, Yuen-Yi;
    • Cowley, Glenn S.;
    • Jonas, Oliver;
    • Cheah, Jaime H.;
    • Kynnap, Bryan D.;
    • Doshi, Mihir B.;
    • Oh, Coyin;
    • Meyer, Stephanie C.;
    • Church, Alanna J.;
    • Gill, Shubhroz;
    • Bielski, Craig M.;
    • Keskula, Paula;
    • Imamovic, Alma;
    • Howell, Sara;
    • Kryukov, Gregory V.;
    • Clemons, Paul A.;
    • Tsherniak, Aviad;
    • Vazquez, Francisca;
    • Crompton, Brian D.
    Publication type:
    Article

  • HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.

    Published in:
    Science Translational Medicine, 2017, v. 9, n. 398, p. 1, doi. 10.1126/scitranslmed.aal5272
    By:
    • Chakraborty, Abhishek A.;
    • Eijiro Nakamura;
    • Jun Qi;
    • Creech, Amanda;
    • Jaffe, Jacob D.;
    • Paulk, Joshiawa;
    • Novak, Jesse S.;
    • Nagulapalli, Kshithija;
    • McBrayer, Samuel K.;
    • Cowley, Glenn S.;
    • Pineda, Javier;
    • Jiaxi Song;
    • Wang, Yaoyu E.;
    • Carr, Steven A.;
    • Root, David E.;
    • Signoretti, Sabina;
    • Bradner, James E.;
    • Kaelin Jr., William G.
    Publication type:
    Article

  • The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection.

    Published in:
    PLoS Pathogens, 2014, v. 10, n. 2, p. 1, doi. 10.1371/journal.ppat.1003904
    By:
    • Filone, Claire Marie;
    • Caballero, Ignacio S.;
    • Dower, Ken;
    • Mendillo, Marc L.;
    • Cowley, Glenn S.;
    • Santagata, Sandro;
    • Rozelle, Daniel K.;
    • Yen, Judy;
    • Rubins, Kathleen H.;
    • Hacohen, Nir;
    • Root, David E.;
    • Hensley, Lisa E.;
    • Connor, John
    Publication type:
    Article

  • Probing the Virus Host Interaction in High Containment: An Approach Using Pooled Short Hairpin RNA.

    Published in:
    Assay & Drug Development Technologies, 2015, v. 13, n. 1, p. 34, doi. 10.1089/adt.2014.613
    By:
    • Filone, Claire Marie;
    • Dower, Ken;
    • Cowley, Glenn S.;
    • Hensley, Lisa E.;
    • Connor, John H.
    Publication type:
    Article

  • Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4.

    Published in:
    Science Translational Medicine, 2012, v. 4, n. 147, p. 1, doi. 10.1126/scitranslmed.3003778
    By:
    • Yin Ren;
    • Hiu Wing Cheung;
    • von Maltzhan, Geoffrey;
    • Agrawal, Amit;
    • Cowley, Glenn S.;
    • Weir, Barbara A.;
    • Boehm, Jesse S.;
    • Tamayo, Pablo;
    • Karst, Alison M.;
    • Liu, Joyce F.;
    • Hirsch, Michelle S.;
    • Mesirov, Jill P.;
    • Drapkin, Ronny;
    • Root, David E.;
    • Lo, Justin;
    • Fogal, Valentina;
    • Ruoslahti, Erkki;
    • Hahn, William C.;
    • Bhatia, Sangeeta N.
    Publication type:
    Article

  • In vivo discovery of immunotherapy targets in the tumour microenvironment.

    Published in:
    Nature, 2014, v. 506, n. 7486, p. 52, doi. 10.1038/nature12988
    By:
    • Zhou, Penghui;
    • Shaffer, Donald R.;
    • Alvarez Arias, Diana A.;
    • Nakazaki, Yukoh;
    • Pos, Wouter;
    • Torres, Alexis J.;
    • Cremasco, Viviana;
    • Dougan, Stephanie K.;
    • Cowley, Glenn S.;
    • Elpek, Kutlu;
    • Brogdon, Jennifer;
    • Lamb, John;
    • Turley, Shannon J.;
    • Ploegh, Hidde L.;
    • Root, David E.;
    • Love, J. Christopher;
    • Dranoff, Glenn;
    • Hacohen, Nir;
    • Cantor, Harvey;
    • Wucherpfennig, Kai W.
    Publication type:
    Article

  • Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.

    Published in:
    Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06140-6
    By:
    • Mittal, Karuna;
    • Cooper, Garrett W.;
    • Lee, Benjamin P.;
    • Su, Yongdong;
    • Skinner, Katie T.;
    • Shim, Jenny;
    • Jonus, Hunter C.;
    • Kim, Won Jun;
    • Doshi, Mihir;
    • Almanza, Diego;
    • Kynnap, Bryan D.;
    • Christie, Amanda L.;
    • Yang, Xiaoping;
    • Cowley, Glenn S.;
    • Leeper, Brittaney A.;
    • Morton, Christopher L.;
    • Dwivedi, Bhakti;
    • Lawrence, Taylor;
    • Rupji, Manali;
    • Keskula, Paula
    Publication type:
    Article

  • A comprehensive platform for highly multiplexed mammalian functional genetic screens.

    Published in:
    BMC Genomics, 2011, v. 12, p. 1, doi. 10.1186/1471-2164-12-213
    By:
    • Ketela, Troy;
    • Heisler, Lawrence E;
    • Brown, Kevin R;
    • Ammar, Ron;
    • Kasimer, Dahlia;
    • Surendra, Anuradha;
    • Ericson, Elke;
    • Blakely, Kim;
    • Karamboulas, Dina;
    • Smith, Andrew M;
    • Durbic, Tanja;
    • Arnoldo, Anthony;
    • Cheung-Ong, Kahlin;
    • Koh, Judice LY;
    • Gopal, Shuba;
    • Cowley, Glenn S;
    • Yang, Xiaoping;
    • Grenier, Jennifer K;
    • Giaever, Guri;
    • Root, David E
    Publication type:
    Article

  • A comprehensive platform for highly multiplexed mammalian functional genetic screens.

    Published in:
    BMC Genomics, 2011, v. 12, n. 1, p. 213, doi. 10.1186/1471-2164-12-213
    By:
    • Ketela, Troy;
    • Heisler, Lawrence E.;
    • Brown, Kevin R.;
    • Ammar, Ron;
    • Kasimer, Dahlia;
    • Surendra, Anuradha;
    • Ericson, Elke;
    • Blakely, Kim;
    • Karamboulas, Dina;
    • Smith, Andrew M.;
    • Durbic, Tanja;
    • Arnoldo, Anthony;
    • Kahlin Cheung-Ong;
    • Koh, Judice L. Y.;
    • Gopal, Shuba;
    • Cowley, Glenn S.;
    • Xiaoping Yang;
    • Grenier, Jennifer K.;
    • Giaever, Guri;
    • Root, David E.
    Publication type:
    Article

  • The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation.

    Published in:
    Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-04139-5
    By:
    • Bhogal, Balpreet;
    • Weir, Barbara A.;
    • Crescenzo, Ramona;
    • Marien, Ann;
    • Kwon, Min Chul;
    • Philippar, Ulrike;
    • Cowley, Glenn S.
    Publication type:
    Article

  • A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16517-w
    By:
    • Eller, Carla;
    • Heydmann, Laura;
    • Colpitts, Che C.;
    • El Saghire, Houssein;
    • Piccioni, Federica;
    • Jühling, Frank;
    • Majzoub, Karim;
    • Pons, Caroline;
    • Bach, Charlotte;
    • Lucifora, Julie;
    • Lupberger, Joachim;
    • Nassal, Michael;
    • Cowley, Glenn S.;
    • Fujiwara, Naoto;
    • Hsieh, Sen-Yung;
    • Hoshida, Yujin;
    • Felli, Emanuele;
    • Pessaux, Patrick;
    • Sureau, Camille;
    • Schuster, Catherine
    Publication type:
    Article