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- Title
Investigation of the Effect of Agomelatine on Cellular and Humoral Immunity in Mice.
- Authors
Naphade, Vaishali D.; Parihar, Gaurav; Jain, D. K.; Bendale, Atul R.
- Abstract
Agomelatine has primarily been described as an antidepressant drug in laborartory animals. In the present study Agomelatine showed an overall stimulatory effect on the specific as well as non-specific immune functions in mice. Stimulatory effects were observed at 25 mg/kg. Administration of Agomelatinein humans is simple as it is readily available as dosage form. Its reported immunomodulatory effects warrant further investigation for its use in the cases of clinical immunostimulation. The present result suggests that Agomelatine may stimulate both the cellular and humoral immunity. Further experimentation is needed in order to understand the precise mechanism of action for the stimulatory effect of the drug. Effects were evaluated at different doses of 1, 5 and 25mg/kg using various parameters like effect on hematological parameters. And the results were further utilized to evaluate the activity on the cellular and humoral branches of immunity.
- Subjects
CELLULAR immunity; HUMORAL immunity; PHARMACOLOGY; VETERINARY drugs
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 7, p49
- ISSN
0976-7126
- Publication type
Article