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- Title
The anticonvulsant effect of aqueous and ethanolic extracts of Lippia citriodora aerial parts and its main constituent verbascoside in mice.
- Authors
Razavi, Bibi Marjan; Nasiri, Adeleh; Hosseinzadeh, Hossein
- Abstract
Objectives: In the present study, the effects of Lippia citriodora and its active ingredients, verbascoside, on seizures induced by pentylenetetrazol (PTZ) and maximal electroshock models were evaluated. Materials and Methods: Aqueous and ethanolic extracts (200, 400 and 600 mg/kg) of Lippia citriodora, as well as verbascoside (100, 200 and 400 mg/kg) were applied in mice. Normal saline (10 ml/kg) as the negative control and diazepam (2 mg/kg) as the positive control were also used. In PTZ test, latency to first minimal clonic seizure, latency to first generalized tonic clonic seizures (GTCS), total duration of seizures and protection against mortality were evaluated. In electro-shock test, stretching length of extremities and protection against mortality were recorded. Results: In PTZ model, aqueous extract (600 mg/kg) increased GTCS latencies. Three doses of aqueous extract decreased the total duration of seizure. Ethanolic (400 and 600 mg/kg) increased GTCS latencies. Moreover, three doses of ethanolic extracts decreased total duration of seizures. Three doses of verbascoside decreased total duration of seizure. These agents did not show any protective effects on seizure induced by MES model. In PTZ model, flumazenil, did not inhibit the prolongation of seizure latency induced by these agents, 7- nitro-indazole on the other hand, inhibited the prolongation of seizure latency. Conclusion: Results of this study demonstrated that aqueous and ethanolic extracts of Lippia citriodora leaves could have anticonvulsant activity in the PTZ model and this effect may be mediated, at least partly, through interaction with nitric oxide.
- Subjects
LIPPIA (Genus); ANTICONVULSANTS; VERBASCOSIDE
- Publication
Avicenna Journal of Phytomedicine, 2015, Vol 5, p60
- ISSN
2228-7930
- Publication type
Article