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- Title
Associations between body composition profile and hypertension in different fatty liver phenotypes.
- Authors
Xiaoyin Huang; Yuchen Zeng; Mingyang Ma; Liangguang Xiang; Qingdan Liu; Ling Xiao; Ruimei Feng; Wanxin Li; Xiaoling Zhang; Moufeng Lin; Zhijian Hu; Hongwei Zhao; Shanshan Du; Weimin Ye
- Abstract
Background: It is currently unclear whether and how the association between body composition and hypertension varies based on the presence and severity of fatty liver disease (FLD). Methods: FLD was diagnosed using ultrasonography among 6,358 participants. The association between body composition and hypertension was analyzed separately in the whole population, as well as in subgroups of non-FLD, mild FLD, and moderate/severe FLD populations, respectively. The mediation effect of FLD in their association was explored. Results: Fat-related anthropometric measurements and lipid metabolism indicators were positively associated with hypertension in both the whole population and the non-FLD subgroup. The strength of this association was slightly reduced in the mild FLD subgroup. Notably, only waist-to-hip ratio and waist-to-height ratio showed significant associations with hypertension in the moderate/severe FLD subgroup. Furthermore, FLD accounted for 17.26% to 38.90% of the association between multiple body composition indicators and the risk of hypertension. Conclusions: The association between body composition and hypertension becomes gradually weaker as FLD becomes more severe. FLD plays a significant mediating role in their association.
- Subjects
FATTY liver; HYPERTENSION; WAIST-hip ratio; LIPID metabolism; BODY composition; PHENOTYPES
- Publication
Frontiers in Endocrinology, 2023, p1
- ISSN
1664-2392
- Publication type
Article
- DOI
10.3389/fendo.2023.1247110