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- Title
PSD-95 Interacts with Dopamine D1-Receptor: Functional Implication.
- Authors
Lingyong Li; Peihua Sun; Xuechu Zhen
- Abstract
Dopamine (DA) system plays critical roles in many aspects of brain function. Abnormal dopaminergic activity is closely related to Parkinson's disease, schizophrenia, drug addiction and other neurological and psychiatric disorders. Postsynaptic density (PSD)-95, a scaffolding molecule, enriched at glutamatergic synapses, is found to have important functions in the modulation of clustering of several neurotransmitter receptor, adhesion molecules, ion channels, cytoskeletal elements and signaling molecules at postsynaptic areas. In this review we will highlight the role of PSD-95 in the interaction and regulation of DA receptors. We will also discuss the importance of PSD-95 in the regulation D1 and N-methyl-D-aspartate (NMDA) receptor functional coupling.
- Subjects
DOPAMINE; DOPAMINERGIC mechanisms; TISSUE scaffolds; PSYCHIATRIC research; SYNAPSES
- Publication
American Journal of Biomedical Sciences, 2011, Vol 3, Issue 4, p313
- ISSN
1937-9080
- Publication type
Article
- DOI
10.5099/aj110400313