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- Title
Does the Cell Wall Skeleton from Bacille Calmette-Guérin Directly Induce Interferon Independent of Interleukin-12?
- Authors
Hayashi, Akira; Noda, Atsunari
- Abstract
Interleukin-12 (IL-12), known to be a strong inducer of interferon-γ (IFN-γ), plays a vital role in activating the immune surveillance system against intracellular pathogens and malignant tumors. The authors have found that cancer patients showing marked IFN-γ induction after inoculation with BCG-CWS (the cell wall skeleton from Bacille Calmette-Guerin) have a good prognosis. The present study was undertaken to determine whether the level of IL-12 is increased prior to, or along with, IFN-γ induction in the serum of patients inoculated with BCG-CWS. Unexpectedly, we found no detectable amount of IL-12 in the serum throughout the entire time course. This suggests that a novel IFN-γ inducing factor (IGIF) or another unknown IFN-γ inducer may be working in place of IL-12 in the BCG-CWS system.
- Publication
Japanese Journal of Clinical Oncology, 1996, Vol 26, Issue 3, p124
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/oxfordjournals.jjco.a023194