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- Title
Mechanistic Insights for Nitromethane Activation into Reactive Nitrogenating Reagents.
- Authors
Qu, Zheng‐Wang; Zhu, Hui; Grimme, Stefan
- Abstract
Recently, it was found that nitromethane (CH3NO2) can be activated into a useful nitrogenating reagent for the synthesis of amide and nitrile compounds. In this work, the mechanisms of CH3NO2 activation are explored in detail by extensive DFT calculations. In aqueous triflic acid (HOTf) solution, the formal 1,3‐H‐shift of CH3NO2 into transient CH2=NO2H is identified as the rate‐limiting step over a barrier of 29.6 kcal/mol, followed by multistep acid hydrolysis to cleave the C=N bond to form NH3OH+ (and HCOOH) as final product. In contrast, in non‐aqueous acetic acid (AcOH) solution with electrophilic Tf2O and nucleophilic HCOOH additives, the C=N bond is cleaved by sequential steps of H2O elimination, electrophilic Tf2O activation, nucleophilic HCOOH addition and acetate/TfO− exchange, affording AcONH3+ as more reactive nitrogenating reagent for Beckmann‐type reactions.
- Subjects
NITROMETHANE; HYDROLYSIS
- Publication
ChemCatChem, 2021, Vol 13, Issue 9, p2132
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.202100086