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- Title
Chemoenzymatic Halogenation of Phenols by using the Haloperoxidase from Curvularia inaequalis.
- Authors
Fernández ‐ Fueyo, ElENa; van WingerdEN, Marco; RENirie, Rokus; Wever, Ron; Ni, Yan; Holtmann, Dirk; Hollmann, Frank
- Abstract
The vanadium-dependent chloroperoxidase from Curvularia inaequalis is an efficient biocatalyst for the in situ generation of hypohalous acids and subsequent electrophilic oxidation/ halogenation reactions. Especially, its superb activity and stability under operational conditions make it an attractive catalyst for organic synthesis. Herein, the efficient bromination of thymol was investigated, and turnover numbers of the enzyme were found to exceed 2000 000. The major novelty of the work is that vanadium chloroperoxidase is more useful as a brominating enzyme than vanadium bromoperoxidase in terms of operational stability, besides being far more stable than hemecontaining peroxidases.
- Subjects
HALOGENATION; PHENOLS; CHLOROPEROXIDASE; HYPOHALOUS acid; ELECTROPHILIC addition reactions; CATALYSTS; ORGANIC synthesis
- Publication
ChemCatChem, 2015, Vol 7, Issue 24, p4035
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.201500862