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- Title
Effect of BNT162b2 booster dose on anti-SARS-CoV-2 spike trimeric IgG antibodies in seronegative individuals.
- Authors
Salvagno, Gian Luca; Henry, Brandon M.; Pighi, Laura; De Nitto, Simone; Gianfilippi, Gianluca; Lippi, Giuseppe
- Abstract
Similarly, the rate of subjects with anti-SARS-CoV-2 spike trimeric IgG values >264 kBAU/L reached 100% after 1 month from completing the primary vaccination cycle, but then decreased to 77.4% and 47.2% after 6 months and immediately before receiving the vaccine booster dose, respectively (Figure 2). Keywords: antibodies; COVID-19; immune response; SARS-CoV-2; vaccination EN antibodies COVID-19 immune response SARS-CoV-2 vaccination 930 933 4 05/12/22 20220501 NES 220501 Introduction Several lines of evidence now attest that laboratory medicine plays an essential role not only in diagnosing acute SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infections, but also for predicting and monitoring the efficacy of coronavirus disease 2019 (COVID-19) vaccination [[1]]. Moreover, we also showed that the vaccine booster dose is effective to increase anti-SARS-CoV-2 spike trimeric IgG antibodies levels by nearly threefold compared to immediately after completing the primary vaccination cycle.
- Subjects
BOOSTER vaccines; COVID-19; SARS-CoV-2; IMMUNOGLOBULIN G; COVID-19 vaccines; MEDICAL personnel; VIRAL antibodies
- Publication
Clinical Chemistry & Laboratory Medicine, 2022, Vol 60, Issue 6, p930
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2022-0212