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- Title
Perinatal asphyxia partly affects presepsin urine levels in non-infected term infants.
- Authors
Botondi, Valentina; Pirra, Alice; Strozzi, Mariachiara; Perrotta, Marika; Gavilanes, Danilo A.W.; Di Ricco, Laura; Spagnuolo, Cynzia; Maconi, Antonio; Rocchetti, Andrea; Mazzucco, Laura; Balbo, Valeria; Schena, Federico; Stellitano, Giuseppina; Oddi, Arianna; Dotta, Andrea; Bersani, Iliana; Sannia, Andrea; Peila, Chiara; Bertino, Enrico; Bianco, Ines
- Abstract
Standard of care sepsis biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT) can be affected by several perinatal factors, among which perinatal asphyxia (PA) has a significant role. In this light, new early sepsis biomarkers such as presepsin (P-SEP) are needed to enact therapeutic strategies at a stage when clinical and laboratory patterns are still silent or unavailable. We aimed at investigating the potential effects of PA on longitudinal P-SEP urine levels. We conducted an observational case-control study in 76 term infants, 38 with PA and 38 controls. Standard clinical, laboratory, radiological monitoring procedures and P-SEP urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Higher (p<0.05) CRP and PCT blood levels at T1–T3 were observed in PA than control infants whilst no differences (p>0.05, for all) at T0 were observed between groups. P-SEP urine levels were higher (p<0.05) in PA at first void and at 24 h while no differences (p>0.05) at 48 and 96 h were observed. No significant correlations were found (p>0.05) between P-SEP and urea (R=0.11) and creatinine (R=0.02) blood levels, respectively. The present results, showed that PA effects on P-SEP were limited up to the first 24 h following birth in absence of any kidney function bias. Data open the way to further investigations aimed at validating P-SEP assessment in non-invasive biological fluids as a reliable tool for early EOS and LOS detection in high-risk infants.
- Subjects
ASPHYXIA neonatorum; INFANTS; KIDNEY physiology; URINE; C-reactive protein; SEPSIS
- Publication
Clinical Chemistry & Laboratory Medicine, 2022, Vol 60, Issue 5, p793
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2022-0027