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- Title
Blood lactate concentration in COVID-19: a systematic literature review.
- Authors
Carpenè, Giovanni; Onorato, Diletta; Nocini, Riccardo; Fortunato, Gianmarco; Rizk, John G.; Henry, Brandon M.; Lippi, Giuseppe
- Abstract
Here we report the results of a systematic review aimed at exploring the possible association between increased blood lactate levels, disease severity and mortality in COVID-19 patients, including a comparison of lactate values between COVID-19 and non-COVID-19 patients. Keywords: COVID-19; lactate; lactic acid; SARS-CoV-2; systematic literature review EN COVID-19 lactate lactic acid SARS-CoV-2 systematic literature review 332 337 6 02/07/22 20220201 NES 220201 Introduction Coronavirus disease 2019 (COVID-19), a new life-threatening infectious pathology caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is generating dramatic clinical impacts worldwide, with substantial derangements in the organization of healthcare, society and economy. It is important to underpin that most COVID-19 patients in the studies included in our analysis did not have baseline hyperlactatemia and that substantially elevated blood lactate values were often absent in many COVID-19 patients who developed unfavourable clinical outcomes (Tables 1-3). This hypothesis is confirmed by evidence that patients with COVID-19 pneumonia or ARDS present with lower blood lactate values compared to those with non-COVID-19 pneumonia or ARDS of different aetiologies (Table 4).
- Subjects
COVID-19; BLOOD lactate; COVID-19 pandemic
- Publication
Clinical Chemistry & Laboratory Medicine, 2022, Vol 60, Issue 3, p332
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2021-1115