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- Title
SAA1 genetic polymorphisms are associated with plasma glucose concentration in non-diabetic subjects.
- Authors
Xie, Xiang; Ma, Yi-Tong; Yang, Yi-Ning; Li, Xiao-Mei; Zheng, Ying-Ying; Fu, Zhen-Yan; Ma, Xiang; Liu, Fen; Huang, Ying; Chen, Bang-Dang
- Abstract
Background: Serum amyloid A (SAA) was reported to be associated with insulin resistance and type-2 diabetes. The present study aimed to investigate the association of SAA genetic polymorphisms with plasma glucose levels in non-diabetic subjects. Methods: All participants (n=1220) were selected from subjects participating in the Cardiovascular Risk Survey (CRS) study. Five single-nucleotide polymorphisms (SNPs) (rs2229338, rs12218, rs4638289, rs7131332 and rs11603089) of SAA gene were genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis. Results: In the present study, we found rs2229338, rs4638289 and rs12218 were significantly associated with plasma glucose levels in a dominate model, recessive model or additive model before and after multivariate adjustment (all p<0.05). These associations were not found in rs7131332 and rs11603089 before and after adjustment of key co-variants. Conclusions: The genetic polymorphisms of SAA1 were associated with plasma glucose levels in non-diabetic subjects.
- Subjects
AMYLOID; GENETIC polymorphism research; TYPE 2 diabetes; BLOOD sugar; CLINICAL pathology
- Publication
Clinical Chemistry & Laboratory Medicine, 2013, Vol 51, Issue 12, p2331
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2013-0097