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- Title
Pubertální růst dětí, které se narodily malé na svůj gestační věk (SGA), s malou výškou v dětství (SGA-SS). Výsledky léčby růstovým hormonem z dat české národní databáze REPAR
- Authors
Aneta, Kodytková; Lukáš, Plachý; Barbora, Jírová; Irena, Hainerová Aldhoon; Darina, Aleksijevi; Jana, Černá; Marcela, Dvořáková; Eva, El-Lababidi; Božena, Kalvachová; Kamila, Kocourková; Ivana, Kotvalová; Olga, Magnová; Dana, Novotná; Barbora, Obermannová; Renata, Pomahačová; Štěpánka, Průhová; Ondřej, Souček; Jiří, Strnadel; Lucie, Šíchová; Jaroslav, Škvor
- Abstract
Both pre-pubertal growth and magnitude of the pubertal growth spurt are the prerequisites of potential of growth hormone therapy to optimize final height. We analyzed impact of pre-pubertal and pubertal growth components on the total effect of growth hormone therapy in a cohort of 397 children (221 boys) registered in the Czech national database of growth hormone recipients REPAR. All were born small for gestational age, had persistent short stature in childhood (SGA-SS) and already achieved their near-final height. We separately evaluated children according to parental heights (with both parents over −2 ht-SDS, one below −2 ht-SDS, both below −2 ht-SDS) and according to their size at birth – low birth weight, low birth length, low both parameters. Up to treatment completion, treatment led to a height gain of 1,59 ht-SDS; of this, the pre-pubertal gain was 1,57 ht-SDS. Thus, ht-SDS remained unchanged within puberty, despite continuous growth hormone administration. The final ht-SDS gain adjusted for age 18 years was 0,91 (all three parameters p<0.0001 if compared to pre-treatment). Children with both parents taller than −2 SD and children with exclusively low birth weight had significantly better treatment outcomes. Analysis results of the REPAR database confirm efficacy of growth hormone therapy in SGA-SS children. The treatment success is based on pre-pubertal growth component. Therefore, a careful follow-up of children born SGA and a timely initiation of growth hormone therapy in early childhood are of crucial importance.
- Subjects
SMALL for gestational age; LOW birth weight; BIRTH size; SOMATOTROPIN; HORMONE therapy
- Publication
Czecho-Slovak Pediatrics / Česko-Slovenská Pediatrie, 2023, Vol 78, p30
- ISSN
0069-2328
- Publication type
Article