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- Title
Short-Term Aerobic Exercise Reduces Arterial Stiffness in Older Adults With Type 2 Diabetes, Hypertension, and Hypercholesterolemia.
- Authors
Madden, Kenneth M.; Lockhart, Chris; Cuff, Darcye; Potter, Tiffany F.; Meneilly, Graydon S.
- Abstract
OBJECTIVE -- The relationship between increased arterial stiffness and cardiovascular mortality is well established in type 2 diabetes. We examined whether aerobic exercise could reduce arterial stiffness in older adults with type 2 diabetes complicated by comorbid hypertension and hyperlipidemia. RESEARCH DESIGN AND METHODS -- A total of 36 older adults (mean age 71.4 ± 0.7 years) with diet-controlled or oral hypoglycemic-controlled type 2 diabetes, hypertension, and hypercholesterolemia were recruited. Subjects were randomly assigned to one of two groups: an aerobic group (3 months vigorous aerobic exercise) and a nonaerobic group (no aerobic exercise). Exercise sessions were supervised by a certified exercise trainer three times per week, and a combination of cycle ergometers and treadmills was used. Arterial stiffness was measured using the Complior device. RESULTS -- When the two groups were compared, aerobic training resulted in a decrease in measures of both radial (-20.7 ± 6.3 vs. ± 8.5 ± 6.6%, P = 0.005)and femoral (-13.9 ± 6.7 vs. +4.4 ± 3.3%, P = 0.015) pulse-wave velocity despite the fact that aerobic fitness as assessed by Vo[sub 2max] did not demonstrate an improvement with training (P = 0.026). CONCLUSIONS -- Our findings indicate that a relatively short aerobic exercise intervention in older adults can reduce multifactorial arterial stiffness (type 2 diabetes, aging, hypertension, and hypercholesterolemia).
- Subjects
AEROBIC exercises; EXERCISE therapy; ARTERIAL diseases; HEALTH of older people; PEOPLE with diabetes; HYPERTENSION; HYPERCHOLESTEREMIA; PATIENTS
- Publication
Diabetes Care, 2009, Vol 32, Issue 8, p1531
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc09-0149