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- Title
Treatment of gingivitis is associated with reduction of systemic inflammation and improvement of oral health‐related quality of life: A randomized clinical trial.
- Authors
Perić, Marina; Marhl, Urska; Gennai, Stefano; Marruganti, Crystal; Graziani, Filippo
- Abstract
Aim: To compare the level of inflammatory markers, oral health‐related quality of life (OHRQoL), and gingival parameters 1 month after introduction of electric toothbrush and intensive oral hygiene manoeuvre adaptation (OHI) versus routine habits (no‐OHI) in patients affected by generalized gingivitis. Materials and Methods: One hundred forty subjects with generalized gingivitis were randomized to receive either OHI or no‐OHI. Full‐mouth plaque/bleeding scores (FMPS/FMBS), serum high‐sensitivity C‐reactive protein (hs‐CRP), interleukin‐6 (IL‐6), and an oral health impact profile‐14 questionnaire were collected at baseline and at 1‐month follow‐up visit. Results: In the OHI, a significant FMPS and FMBS reduction (p <.01), a significant intra‐group decrease in hs‐CRP and IL‐6 (p <.01), and a significant improvement of OHRQoL (p <.01) were noted at 1‐month follow‐up visit. In the no‐OHI, lower‐magnitude differences were noted only for oral parameters. Resolution of gingivitis varied between OHI and no‐OHI (89% vs. 7%, respectively, p <.01). A logistic multivariate regression suggested that FMBS ≤8% was associated with the odds ratio of 13, having both CRP and IL‐6 below the selected threshold for healthy young adults (p =.04). Conclusions: Gingivitis resolution determined important reductions of gingival inflammation and plaque levels, as well as systemic inflammatory markers and an improvement of quality of life (NCT03848351).
- Subjects
INFLAMMATION prevention; C-reactive protein; INTERLEUKINS; GINGIVITIS; DENTAL plaque; ORAL health; TOOTH care &; hygiene; MULTIPLE regression analysis; RANDOMIZED controlled trials; QUALITY of life; QUESTIONNAIRES; DESCRIPTIVE statistics; STATISTICAL sampling; INFLAMMATORY mediators; ODDS ratio
- Publication
Journal of Clinical Periodontology, 2022, Vol 49, Issue 9, p899
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.13690