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- Title
Increased Serum CA125 Levels in Plasma Cell Dyscrasias.
- Authors
Iwasaki, Tsuyoshi; Hamano, Teruaki; Aizwa, Kaori; Kobayashi, Kumiko; Kakishit, Eizo
- Abstract
We report 2 cases of plasma cell dyscrasia presenting with significantly elevated serum CA125 levels. The serum levels of CA125 from these patients correlated well with their serum M-protein levels. One patient had an IgG-κ type extramedullary plasmacytoma with the culture supernatant from lymph node plasma cells showing a considerably high level of CA125 activity. The serum IgG fraction purified using a protein A column was devoid of any detectable CA125 activity, negating that the serum IgG M-protein from this patient might respond with a false-positive result in the CA125 immunoradiometric assay. The other patient had an IgG-λ type plasma cell leukemia with the culture supernatant from peripheral mononuclear cells also showing a high level of CA125 activity. These observations may suggest that in plasma cell dyscrasias the CA125 antigen is spontaneously produced by tumor cells. Copyright © 1997 S. Karger AG, Basel
- Publication
Acta Haematologica, 1997, Vol 98, Issue 2, p104
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000203599