We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Anemia and Neutropenia in a Case of Copper Deficiency: Role of Copper in Normal Hematopoiesis.
- Authors
Hirase, Nobuhisa; Abe, Yasunobu; Sadamura, Shingo; Yufu, Yuji; Muta, Koichiro; Umemura, Tsukuru; Nishimura, Junji; Nawata, Hajime; Ideguchi, Hiroshi
- Abstract
We present a patient who developed severe anemia and neutropenia after receiving parenteral nutrition for 2.5 years. The serum levels of copper and ceruloplasmin were low, and the bone marrow showed the presence of ringed sideroblasts and vacuolated immature cells. The administration of copper chloride by bolus injection led to a rapid improvement in anemia and neutropenia. The number of progenitor cells (colony-forming unit-granulocyte-macrophage and erythrocyte) present before the copper supplementation was well preserved. It is therefore suggested that copper enzymes play an important role in the maturation of hematopoietic cells. Copyright © 1992 S. Karger AG, Basel
- Publication
Acta Haematologica, 1992, Vol 87, Issue 4, p195
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000204758