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- Title
The impact of sofosbuvir/daclatasvir or ribavirin in patients with severe COVID-19.
- Authors
Eslami, Gholamali; Mousaviasl, Sajedeh; Radmanesh, Esmat; Jelvay, Saeed; Bitaraf, Saeid; Simmons, Bryony; Wentzel, Hannah; Hill, Andrew; Sadeghi, Anahita; Freeman, James; Salmanzadeh, Shokrollah; Esmaeilian, Hani; Mobarak, Morteza; Tabibi, Ramin; Jafari Kashi, Amir Hosein; Lotfi, Zahra; Talebzadeh, Seyed Mehdi; Wickramatillake, Aseni; Momtazan, Mahboobeh; Hajizadeh Farsani, Majid
- Abstract
<bold>Objectives: </bold>Sofosbuvir and daclatasvir are direct-acting antivirals highly effective against hepatitis C virus. There is some in silico and in vitro evidence that suggests these agents may also be effective against SARS-CoV-2. This trial evaluated the effectiveness of sofosbuvir in combination with daclatasvir in treating patients with COVID-19.<bold>Methods: </bold>Patients with a positive nasopharyngeal swab for SARS-CoV-2 on RT-PCR or bilateral multi-lobar ground-glass opacity on their chest CT and signs of severe COVID-19 were included. Subjects were divided into two arms with one arm receiving ribavirin and the other receiving sofosbuvir/daclatasvir. All participants also received the recommended national standard treatment which, at that time, was lopinavir/ritonavir and single-dose hydroxychloroquine. The primary endpoint was time from starting the medication until discharge from hospital with secondary endpoints of duration of ICU stay and mortality.<bold>Results: </bold>Sixty-two subjects met the inclusion criteria, with 35 enrolled in the sofosbuvir/daclatasvir arm and 27 in the ribavirin arm. The median duration of stay was 5 days for the sofosbuvir/daclatasvir group and 9 days for the ribavirin group. The mortality in the sofosbuvir/daclatasvir group was 2/35 (6%) and 9/27 (33%) for the ribavirin group. The relative risk of death for patients treated with sofosbuvir/daclatasvir was 0.17 (95% CI 0.04-0.73, P = 0.02) and the number needed to treat for benefit was 3.6 (95% CI 2.1-12.1, P < 0.01).<bold>Conclusions: </bold>Given these encouraging initial results, and the current lack of treatments proven to decrease mortality in COVID-19, further investigation in larger-scale trials seems warranted.
- Subjects
SOFOSBUVIR; COVID-19; RIBAVIRIN; HOSPITAL admission &; discharge; HEPATITIS C virus; SARS-CoV-2; VIRAL pneumonia; RESEARCH; COMBINATION drug therapy; CLINICAL trials; RESEARCH methodology; ANTIVIRAL agents; EVALUATION research; MEDICAL cooperation; IMIDAZOLES; TREATMENT effectiveness; COMPARATIVE studies; EPIDEMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2020, Vol 75, Issue 11, p3366
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/dkaa331