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- Title
High Glucose Stimulates Expression of MFHAS1 to Mitigate Inflammation <italic>via</italic> Akt/HO-1 Pathway in Human Umbilical Vein Endothelial Cells.
- Authors
Wang, Hui-hui; Sun, Peng-fei; Chen, Wan-kun; Zhong, Jing; Shi, Qi-qing; Weng, Mei-lin; Ma, Duan; Miao, Chang-hong
- Abstract
Hyperglycemia is a highly dangerous factor to various diseases, even resulting in death of people. Inflammation plays a key role in this process. The aim of this study was to explore the role of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) in high-glucose induced inflammation. Our research showed that high glucose stimulated the expression of MFHAS1, and overexpression of MFHAS1 can attenuate high-glucose induced inflammation in endothelial cells by decreasing the secretion of cytokines interleukin-1β (IL-1β), interleukin-1α (IL-1α), adhesion molecule intercellular adhesion molecule-1 (ICAM), interleukin-6 (IL-6), interleukin-8 (IL-8), and chemokine ligand 1 (CXCL-1). Furthermore, we found that MFHAS1 promoted the phosphorylation of Akt and the expression of heme oxygenase-1 (HO-1). Our results indicated that MFHAS1 deadened high-glucose induced inflammation by activating AKT/HO-1 pathway, suggesting that MFHAS1 may act as a new therapeutic target of diabetes mellitus.
- Subjects
GENE expression; INFLAMMATION; ENDOTHELIAL cells; UMBILICAL veins; HYPERGLYCEMIA; PROTEIN kinase B
- Publication
Inflammation, 2018, Vol 41, Issue 2, p400
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-017-0696-0