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- Title
Enantioselective Allylic Substitution of Morita-Baylis-Hillman Adducts Catalyzed by Chiral Bifunctional Ferrocenylphosphines.
- Authors
Zhu, Linglong; Hu, Haiwen; Qi, Liang; Zheng, Yi; Zhong, Weihui
- Abstract
A series of air-stable chiral ferrocenylphosphines ( LB1- LB4) were prepared and used in the asymmetric allylic substitution of Morita-Baylis-Hillman (MBH) adducts with phthalimide under mild reaction conditions; the ( R, SFc)-ferrocenylphosphine LB4 afforded the desired amination products 3 in moderate yields with excellent enantioselectivities. The absolute configuration of 3o was confirmed by X-ray analysis.
- Subjects
ENANTIOSELECTIVE catalysis; SUBSTITUTION reactions; AMINATION; BAYLIS-Hillman reaction; PHTHALIMIDES
- Publication
European Journal of Organic Chemistry, 2016, Vol 2016, Issue 12, p2139
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201600045