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- Title
The Content Validity of a Chemotherapy-Induced Peripheral Neuropathy Patient-Reported Outcome Measure.
- Authors
Smith, Ellen M. Lavoie; Haupt, Rylie; Kelly IV, James P.; Lee, Deborah; Kanzawa-Lee, Grace; Knoerl, Robert; Bridges, Celia; Alberti, Paola; Prasertsri, Nusara; Donohoe, Clare
- Abstract
Purpose/Objectives: To test the content validity of a 16-item version of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy (QLQ-CIPN20). Research Approach: Cross-sectional, prospective, qualitative design. Setting: Six outpatient oncology clinics within the University of Michigan Health System's comprehensive cancer center in Ann Arbor. Participants: 25 adults with multiple myeloma or breast, gynecologic, gastrointestinal, or head and neck malignancies experiencing peripheral neuropathy caused by neurotoxic chemotherapy. Methodologic Approach: Cognitive interviewing methodology was used to evaluate the content validity of a 16-item version of the QLQ-CIPN20 instrument. Findings: Minor changes were made to three questions to enhance readability. Twelve questions were revised to define unfamiliar terminology, clarify the location of neuropathy, and emphasize important aspects. One question was deleted because of clinical and conceptual redundancy with other items, as well as concerns regarding generalizability and social desirability. Interpretation: Cognitive interviewing methodology revealed inconsistencies between patients' understanding and researchers' intent, along with points that required clarification to avoid misunderstanding. Implications for Nursing: Patients' interpretations of the instrument's items were inconsistent with the intended meanings of the questions. One item was dropped and others were revised, resulting in greater consistency in how patients, clinicians, and researchers interpreted the items' meanings and improving the instrument's content validity. Following additional revision and psychometric testing, the QLQ-CIPN20 could evolve into a goldstandard CIPN patient-reported outcome measure.
- Subjects
MICHIGAN; QUALITY of life; TUMOR classification; ANTINEOPLASTIC agents; CANCER treatment; CONCEPTUAL structures; INTERVIEWING; LONGITUDINAL method; MATHEMATICAL models; RESEARCH methodology; PERIPHERAL neuropathy; QUESTIONNAIRES; RESEARCH evaluation; RESEARCH funding; QUALITATIVE research; THEORY; JUDGMENT sampling; SPECIALTY hospitals; THEMATIC analysis; CROSS-sectional method; RESEARCH methodology evaluation; PATIENTS' attitudes
- Publication
Oncology Nursing Forum, 2017, Vol 44, Issue 5, p580
- ISSN
0190-535X
- Publication type
Article
- DOI
10.1188/17.ONF.580-588