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- Title
Efficacy and Safety of Sofosbuvir/Velpatasvir in Patients With Chronic Hepatitis C Virus Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ASTRAL Trials.
- Authors
Grebely, Jason; Dore, Gregory J.; Zeuzem, Stefan; Aspinall, Richard J.; Fox, Raymond; Han, Lingling; McNally, John; Osinusi, Anu; Brainard, Diana M.; Subramanian, G. Mani; Natha, Macky; Foster, Graham R.; Mangia, Alessandra; Sulkowski, Mark; Feld, Jordan J.
- Abstract
In this analysis of the ASTRAL trials (non-opioid substitution therapy [OST], n = 984; OST, n = 51) evaluating the once-daily, pan-genotypic regimen of sofosbuvir/velpatasvir for hepatitis C virus infection, OST did not impact completion, adherence, sustained virologic response (SVR12), or safety. SVR12 was 96% (95% confidence interval, 87%, >99%) in those receiving OST.
- Subjects
HEPATITIS C treatment; SOFOSBUVIR; HEPATITIS C virus; OPIOIDS; ANTIPYRETICS; PATIENTS
- Publication
Clinical Infectious Diseases, 2016, Vol 63, Issue 11, p1479
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciw579