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- Title
Duration of anaemia during the first week of life is an independent risk factor for retinopathy of prematurity.
- Authors
Lundgren, Pia; Athikarisamy, Sam E.; Simmer, Karen; Patole, Sanjay; Lam, Geoffrey C.; Smith, Lois E.
- Abstract
<bold>Aim: </bold>This study evaluated the correlation between retinopathy of prematurity (ROP), anaemia and blood transfusions in extremely preterm infants.<bold>Methods: </bold>We included 227 infants born below 28 weeks of gestation at King Edward Memorial Hospital, Perth, Australia, from 2014-2016. Birth characteristics and risk factors for ROP were retrieved, and anaemia and severe anaemia were defined as a haemoglobins of <110 g/L and <80 g/L, respectively. Logistic regression was used for the analysis.<bold>Results: </bold>Retinopathy of prematurity treatment was needed in 11% of cases and the mean number of blood transfusions (p < 0.01), and mean number of weeks of anaemia (p < 0.001) and of severe anaemia (p < 0.05), had positive associations with ROP cases warranting treatment. In the multivariate logistic regression analysis, the best-fit model of risk factors included anaemic days during first week of life, with an odds ratio (OR) of 1.46% and 95% confidence interval (CI) of 1.16-1.83 (p < 0.05), sepsis during the first 4 weeks of life (OR 3.14, 95% CI 1.10-9.00, p < 0.05) and days of ventilation (OR 1.03, 95% CI 1.01-1.06, p < 0.05).<bold>Conclusion: </bold>The duration of anaemia during the first week of life was an independent risk factor for ROP warranting treatment and preventing early anaemia may decrease this risk.
- Subjects
RETROLENTAL fibroplasia; NEONATAL anemia; DIAGNOSIS; PREMATURE infant diseases; DISEASE risk factors; PATIENTS; THERAPEUTICS
- Publication
Acta Paediatrica, 2018, Vol 107, Issue 5, p759
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.14187