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- Title
Autocrine release of TGF-β by portal fibroblasts regulates cell growth
- Authors
Wells, Rebecca G.; Kruglov, Emma; Dranoff, Jonathan A.
- Abstract
Portal fibroblasts (PF) are a newly isolated population of fibrogenic cells in the liver postulated to play a significant role in early biliary fibrosis. Because transforming growth factor-β (TGF)-β is a key growth factor in fibrosis, we characterized the response of PF to TGF-β. We demonstrate that PF produce significant amounts of TGF-β2 and, unlike activated hepatic stellate cells (HSC), express all three TGF-β receptors and are growth inhibited by TGF-β1 and TGF-β2. Fibroblast growth factor (FGF)-2, but not platelet derived growth factor (PDGF), causes PF proliferation. These data suggest a mechanism whereby HSC eclipse PF as the dominant myofibroblast population in biliary fibrosis.
- Subjects
TRANSFORMING growth factors-beta; CYSTIC fibrosis; FIBROBLASTS; GENETIC transformation
- Publication
FEBS Letters, 2004, Vol 559, Issue 1-3, p107
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(04)00037-7