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- Title
Observational study of the epidemiology and outcomes of vancomycin-resistant Enterococcus bacteraemia treated with newer antimicrobial agents.
- Authors
McKINNELL, J. A.; PATEL, M.; SHIRLEY, R. M.; KUNZ, D. F.; MOSER, S. A.; BADDLEY, J. W.
- Abstract
Vancomycin-resistant Enterococcus bloodstream infections (VRE-BSI) are a growing problem with few clinical trials to guide therapy. We conducted a retrospective study of management and predictors of mortality for VRE-BSI at a tertiary-care centre from January 2005 to August 2008. Univariate and multivariable analyses examined the relationship of patient characteristics and antibiotic therapy with 30-day all-cause mortality. Rates of VRE-BSI increased from 0·06 to 0·17 infections/1000 patient-days (P=0·03). For 235 patients, 30-day mortality was 34·9%. Patients were primarily treated with linezolid (44·2%) or daptomycin (36·5%). Factors associated with mortality were haemodialysis [odds ratio (OR) 3·2, 95% confidence interval (CI) 1·6–6·3, P=0·007], mechanical ventilation (OR 3·7, 95% CI 1·3–10·4, P=0·01), and malnutrition (OR 2·0, 95% CI 1·0–4·0, P=0·046). Use of linezolid, but not daptomycin (P=0·052) showed a trend towards an association with survival. In conclusion, VRE-BSI is a growing problem, associated with significant 30-day mortality. Multiple factors were associated with poor outcomes at our hospital.
- Subjects
SCIENTIFIC observation; EPIDEMIOLOGY; VANCOMYCIN resistance; ENTEROCOCCAL infections; ANTI-infective agents; NOSOCOMIAL infections; TREATMENT effectiveness; CLINICAL trials
- Publication
Epidemiology & Infection, 2011, Vol 139, Issue 9, p1342
- ISSN
0950-2688
- Publication type
Article
- DOI
10.1017/S0950268810002475