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A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug‐induced toxicity.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 10, p. 1511, doi. 10.1002/psp4.13029
By:
- Gall, Louis;
- Jardi, Ferran;
- Lammens, Lieve;
- Piñero, Janet;
- Souza, Terezinha M.;
- Rodrigues, Daniela;
- Jennen, Danyel G. J.;
- de Kok, Theo M.;
- Coyle, Luke;
- Chung, Seung‐Wook;
- Ferreira, Sofia;
- Jo, Heeseung;
- Beattie, Kylie A.;
- Kelly, Colette;
- Duckworth, Carrie A.;
- Pritchard, D. Mark;
- Pin, Carmen
Publication type:
Article
Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients.
Published in:
PLoS Neglected Tropical Diseases, 2019, v. 13, n. 1, p. 1, doi. 10.1371/journal.pntd.0007026
By:
- Lachau-Durand, Sophie;
- Lammens, Lieve;
- van der Leede, Bas-jan;
- Van Gompel, Jacky;
- Bailey, Graham;
- Lampo, Ann;
- Engelen, Marc
Publication type:
Article
Bilateral Symmetrical Idiopathic Necrotizing Encephalopathy.
Published in:
Toxicologic Pathology, 2015, v. 43, n. 8, p. 1141, doi. 10.1177/0192623315604409
By:
- De Jonghe, Sandra;
- Abbott, David;
- Vinken, Petra;
- Moesen, Esther;
- Feyen, Bianca;
- Lammens, Lieve;
- Vynckier, An;
- De Lahunta, Alexander
Publication type:
Article
Evaluation of miR-122 and Other Biomarkers in Distinct Acute Liver Injury in Rats.
Published in:
Toxicologic Pathology, 2013, v. 41, n. 5, p. 795, doi. 10.1177/0192623312464436
By:
- Starckx, Sofie;
- Batheja, Ameesha;
- Verheyen, Geert R.;
- Jonghe, Sandra De;
- Steemans, Kristel;
- Dijck, Bram Van;
- Singer, Monica;
- Bogdan, Nancy;
- Snoeys, Jan;
- Vinken, Petra;
- Sasaki, Jennifer C.;
- Gompel, Jacky Van;
- Guzzie-Peck, Peggy;
- Lampo, Ann;
- Lammens, Lieve
Publication type:
Article
Phospholipidosis in Rats Treated with Amiodarone: Serum Biochemistry and Whole Genome Micro-Array Analysis Supporting the Lipid Traffic Jam Hypothesis and the Subsequent Rise of the Biomarker BMP.
Published in:
Toxicologic Pathology, 2012, v. 40, n. 3, p. 491, doi. 10.1177/0192623311432290
By:
- Mesens, Natalie;
- Desmidt, Miek;
- Verheyen, Geert R.;
- Starckx, Sofie;
- Damsch, Siegrid;
- Vries, Ronald De;
- Verhemeldonck, Marc;
- Gompel, Jacky Van;
- Lampo, Ann;
- Lammens, Lieve
Publication type:
Article
Unexpected Nasal Changes in Rats Related to Reflux after Gavage Dosing.
Published in:
Toxicologic Pathology, 2011, v. 39, n. 2, p. 337, doi. 10.1177/0192623310388430
By:
- DAMSCH, SIEGRID;
- EICHENBAUM, GARY;
- LOOSZOVA, ADRIANA;
- LAMMENS, LIEVE;
- FEYEN, BIANCA;
- VAN DEN BULCK, KATHLEEN;
- KNIGHT, ELAINE;
- KELLEY, MICHAEL;
- TONELLI, ALFRED
Publication type:
Article
Gavage-Related Reflux in Rats: Identification, Pathogenesis, and Toxicological Implications (Review).
Published in:
Toxicologic Pathology, 2011, v. 39, n. 2, p. 348, doi. 10.1177/0192623310388431
By:
- DAMSCH, SIEGRID;
- EICHENBAUM, GARY;
- TONELLI, ALFRED;
- LAMMENS, LIEVE;
- VAN DEN BULCK, KATHLEEN;
- FEYEN, BIANCA;
- VANDENBERGHE, JOHN;
- MEGENS, ANTON;
- KNIGHT, ELAINE;
- KELLEY, MICHAEL
Publication type:
Article
Hemorrhagic Cardiomyopathy in Male Mice Treated with an NNRTI: The Role of Vitamin K.
Published in:
Toxicologic Pathology, 2008, v. 36, n. 2, p. 321, doi. 10.1177/0192623307311404
By:
- DE JONGHE, SANDRA;
- VERBEECK, JOHAN;
- VINKEN, PETRA;
- LAMMENS, LIEVE;
- STARCKX, SOFIE;
- LACHAU-DURAND, SOPHIE;
- BOUCHE, MARIE-PAULE;
- WILLEMS, BART;
- COUSSEMENT, WERNER
Publication type:
Article
Translational safety biomarkers of colonic barrier integrity in the rat.
Published in:
Journal of Applied Toxicology, 2018, v. 38, n. 10, p. 1282, doi. 10.1002/jat.3639
By:
- Erkens, Tim;
- Bueters, Ruud;
- van Heerden, Marjolein;
- Cuyckens, Filip;
- Vreeken, Rob;
- Goeminne, Nick;
- Lammens, Lieve
Publication type:
Article
Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Healthy Volunteers.
Published in:
Clinical Infectious Diseases, 2023, v. 77, n. 6, p. 857, doi. 10.1093/cid/ciad284
By:
- Ackaert, Oliver;
- Vanhoutte, Frédéric;
- Verpoorten, Nathalie;
- Buelens, Annemie;
- Lachau-Durand, Sophie;
- Lammens, Lieve;
- Hoetelmans, Richard;
- Loock, Marnix Van;
- Herrera-Taracena, Guillermo
Publication type:
Article

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