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- Title
Regulation of arachidonic acid availability for eicosanoid production.
- Authors
Leslie, Christina C.
- Abstract
Mammalian cells have developed specific pathways for the incorporation, remodeling, and release of arachidonic acid. Acyltransferase and transacylase pathways function to regulate the levels of esterified arachidonic acid in specific phospholipid pools. There are several distinct, differentially regulated phospholipases A2 in cells that mediate agonist-induced release of arachidonic acid. These pathways are important in controlling cellular levels of free arachidonic acid. Both arachidonic acid and its oxygenated metabolites are potent bioactive mediators that regulate a myriad of physiological and pathophysiological processes.
- Subjects
ARACHIDONIC acid; EICOSANOIC acid derivatives; PHOSPHOLIPIDS; PHOSPHOLIPASE A2; ACYLTRANSFERASES
- Publication
Biochemistry & Cell Biology, 2004, Vol 82, Issue 1, p1
- ISSN
0829-8211
- Publication type
Article
- DOI
10.1139/O03-080