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- Title
Low-Area Four-Channel Controlled Dielectric Breakdown System Design for Point-of-Care Applications.
- Authors
Hong, Jonggi; Oh, Yeonji; Choi, Hojong; Kim, Jungsuk
- Abstract
In this study, we propose a low-area multi-channel controlled dielectric breakdown (CDB) system that simultaneously produces several nanopore sensors. Conventionally, solid-state nanopores are prepared by etching or drilling openings in a silicon nitride (SiNx) substrate, which is expensive and requires a long processing time. To address these challenges, a CDB technique was introduced and used to fabricate nanopore channels in SiNx membranes. However, the nanopore sensors produced by the CDB result in a severe pore-to-pore diameter variation as a result of different fabrication conditions and processing times. Accordingly, it is indispensable to simultaneously fabricate nanopore sensors in the same environment to reduce the deleterious effects of pore-to-pore variation. In this study, we propose a four-channel CDB system that comprises an amplifier that boosts the command voltage, a 1-to-4 multiplexer, a level shifter, a low-noise transimpedance amplifier and a data acquisition device. To prove our design concept, we used the CDB system to fabricate four nanopore sensors with diameters of <10 nm, and its in vitro performance was verified using λ-DNA samples.
- Subjects
DIELECTRIC breakdown; NANOPORES; SYSTEMS design; POINT-of-care testing; SILICON nitride; LOW noise amplifiers
- Publication
Sensors (14248220), 2022, Vol 22, Issue 5, pN.PAG
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s22051895