We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
OMEPRAZOLE DOSING: AM VS. PM: DOES SUNSET MAKE A DIFFERENCE?
- Authors
DeVault, Ken; Castell, Donald O.
- Abstract
These authors sought to compare the effects of placebo and 20 mg omeprazole, given either in the morning or evening, on gastric acidity, plasma gastrin levels, and plasma omeprazole in six duodenal ulcer patients by aspirating hourly gastric samples for p11 testing. They noted a significant increase in mean 24-h pH over that with placebo (pH = 1.7 ± 0.1), with the morning dose only 3.9 ± 1.8, p < 0.01). The evening dose resulted in a nonsignificant increase in mean gastric pH (2.9 ± 1.1). In addition, the mean time that gastric was pH > 3.0 during the 24-h study was 2 h with placebo, 9.2 h with the evening dose, and 13.8 h with the morning dose. It is interesting that when integrated 24-h acidity was calculated, two of six subjects had little change from placebo with either dose, and one of six had significant acid suppression only with the morning dose. Gastrin levels were not significantly elevated with either dose.
- Subjects
PHARMACODYNAMICS; OMEPRAZOLE; PLACEBOS; GASTRIN; DUODENAL ulcers
- Publication
American Journal of Gastroenterology (Springer Nature), 1993, Vol 88, Issue 1, p150
- ISSN
0002-9270
- Publication type
Article