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- Title
Relationship between race and outcome in Asian, Black, and Caucasian patients with spontaneous intracerebral hemorrhage: Data from the Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke trial.
- Authors
Krishnan, Kailash; Beishon, Lucy; Berge, Eivind; Christensen, Hanne; Dineen, Robert A.; Ozturk, Serefnur; Sprigg, Nikola; Wardlaw, Joanna M.; Bath, Philip M.
- Abstract
Background and purpose: Although poor prognosis after intracerebral hemorrhage relates to risk factors and hematoma characteristics, there is limited evidence for the effect of race-ethnicity. Methods: Data from 1011 patients with intracerebral hemorrhage enrolled into hyperacute trials and randomized to control were obtained from the Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke Trial. Clinical characteristics and functional outcome were compared among three racial groups - Asians, Blacks, and Caucasians. Results: The majority of patients were Caucasian (78.1%) followed by Asians (14.5%) and Blacks (5.5%). At baseline, Caucasians were older and had larger hematoma volumes; Blacks had lower Glasgow Coma Scale and higher systolic blood pressure (all p<0.05). Although the primary outcome of modified Rankin Scale did not differ at 90 days (p=0.14), there were significant differences in mortality (p<0.0001) and quality of life (EQ-5D p<0.0001; EQ-VAS p 0.015). In test of multiple comparisons, Caucasians were more likely to die (p=0.0003) and had worse quality of life (EQ-5D p=0.003; EQ-VAS p<0.0001) as compared to Asians. Conclusion: Race-ethnicity appears to explain some of the variation in clinical characteristics and outcomes after acute intracerebral hemorrhage. Factors that explain this variation need to be identified.
- Subjects
CEREBRAL hemorrhage; CEREBROVASCULAR disease diagnosis; STROKE treatment; THERAPEUTIC use of nitric oxide; STROKE patients; PROGNOSIS
- Publication
International Journal of Stroke, 2018, Vol 13, Issue 4, p362
- ISSN
1747-4930
- Publication type
Article
- DOI
10.1177/1747493017744463