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- Title
Copeptin and risk stratification in patients with ischemic stroke and transient ischemic attack: The Co Risk Study.
- Authors
De Marchis, Gian Marco; Katan, Mira; Weck, Anja; Brekenfeld, Caspar; Mattle, Heinrich P; Buhl, Daniela; Müller, Beat; Christ-Crain, Mirjam; Arnold, Marcel
- Abstract
Rationale Copeptin independently predicts functional outcome and mortality at 90 days and one-year after ischemic stroke. In patients with transient ischemic attack, elevated copeptin values indicate an increased risk of further cerebrovascular events. Aims The Copeptin Risk Stratification ( Co Risk) study aims to validate the predictive value of copeptin in patients with ischemic stroke and transient ischemic attack. In patients with ischemic stroke, the Co Risk study aims to further explore the effect of treatment (i.e. thrombolysis) on the predictive value of copeptin. Design Prospective observational multicenter study analyzing three groups of patients, i.e. patients with ischemic stroke treated with and without thrombolysis and patients with transient ischemic attack. Outcomes Primary end-point: In patients with ischemic stroke, the primary end-point includes disability (modified Rankin scale from 3 to 5) and mortality (modified Rankin scale 6) at three-months after stroke. In patients with transient ischemic attack, the primary end-point is a recurrent ischemic cerebrovascular event (i.e. ischemic stroke or recurrent transient ischemic attack). Secondary end-point: In patients with ischemic stroke, the secondary end-points include in-house complications (i.e. symptomatic intracerebral hemorrhage, malignant edema, aspiration pneumonia or seizures during hospitalization, and in-house mortality).
- Subjects
PHYSIOLOGICAL effects of peptides; ISCHEMIA; STROKE; DISEASE risk factors; DEATH rate
- Publication
International Journal of Stroke, 2013, Vol 8, Issue 3, p214
- ISSN
1747-4930
- Publication type
Article
- DOI
10.1111/j.1747-4949.2011.00762.x