The article discusses the "Natural History of Infantile Onset Spinal Muscular Atrophy" study by Stephen J. Kolb of the Ohio State University Wexner Medical Center in the issue. Topics discussed include applications issued to develop better biomarkers in spinal muscular atrophy (SMA), data supported by Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT) and newborn screening for SMA.