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- Title
Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis.
- Authors
Maleki, Azam; Bashirian, Saeid; Soltanian, Ali Reza; Jenabi, Ensiyeh; Farhadinasab, Abdollah
- Abstract
Background: There is evidence of a relationship between prenatal excess androgen exposure and central nervous developmental problems and attentiondeficit/hyperactivity disorder (ADHD) in the offspring of mothers with polycystic ovary syndrome (PCOS). Purpose: Here we aimed to use a metaanalysis to investigate whether the offspring of mothers with PCOS are at an increased chance of developing ADHD. Methods: Three main English databases were searched for articles published through December 2020. The NewcastleOttawa Scale was used to assess study quality. Study heterogeneity was determined using I 2 statistics and publication bias was assessed using Begg and Egger tests. The results are presented as odds ratio (OR) and relative ratio (RR) estimates with 95% confidence intervals (CIs) using a randomeffects model. Results: Six articles (3 cohort and 3 casecontrol studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on OR and RR (OR, 1.42; 95% CI, 1.27–1.57) and (RR, 1.43; 95% CI, 1.35–1.51), respectively. There was no heterogeneity among the included articles based on OR ( I 2= 0.0%, P =0.588) and RR ( I 2=0.0%, P =0.878). Conclusion: Our study showed that maternal PCOS is a risk factor for ADHD. Therefore, screening their offspring for ADHD should be considered part of the comprehensive clinical care of women with PCOS.
- Subjects
POLYCYSTIC ovary syndrome; ATTENTION-deficit hyperactivity disorder; TIC disorders; STATISTICAL bias
- Publication
Clinical & Experimental Pediatrics, 2022, Vol 65, Issue 2, p85
- ISSN
2713-4148
- Publication type
Article
- DOI
10.3345/cep.2021.00178