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- Title
Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study.
- Authors
Sun Q; van Dam RM; Meigs JB; Franco OH; Mantzoros CS; Hu FB; Sun, Qi; van Dam, Rob M; Meigs, James B; Franco, Oscar H; Mantzoros, Christos S; Hu, Frank B
- Abstract
<bold>Objective: </bold>We prospectively examined plasma levels of leptin and soluble leptin receptor (sOB-R), as well as their interactions with other diabetes risk factors, in relation to type 2 diabetes to elucidate the complex relation between these two biomarkers and diabetes risk.<bold>Research Design and Methods: </bold>Of 32,826 Nurses' Health Study participants who provided blood samples during 1989-1990, 1,054 incident case subjects of type 2 diabetes were identified and confirmed during 1990-2004 and 1,254 matched control subjects were selected. Plasma leptin and sOB-R levels were measured among these participants.<bold>Results: </bold>After multivariate adjustment for BMI, lifestyle practices, and dietary factors, sOB-R levels were significantly associated with a lower risk of type 2 diabetes. In comparison with women in the lowest quintile, the ORs (95% CI) of developing type 2 diabetes were 0.73 (0.55-0.96), 0.51 (0.38-0.68), 0.42 (0.31-0.57), and 0.39 (0.28-0.54; P for trend < 0.0001) for women in the second to fifth quintiles of sOB-R levels, respectively. In contrast, plasma leptin levels were not significantly associated with the risk of type 2 diabetes: The OR (95% CI) was 0.82 (0.62-1.10; P for trend = 0.46) comparing the highest with the lowest quintile of leptin levels. sOB-R levels were consistently associated with a decreased risk of type 2 diabetes at various levels of leptin or high-molecular-weight adiponectin.<bold>Conclusions: </bold>These data suggest a strong inverse association between plasma sOB-R levels and risk of type 2 diabetes, independent of BMI, leptin, and adiponectin levels.
- Publication
Diabetes, 2010, Vol 59, Issue 3, p611
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/db09-1343