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- Title
Isopropoxy Benzene Guanidine Ameliorates Streptococcus suis Infection In Vivo and In Vitro.
- Authors
Han, Ning; Li, Jie; Zhao, Feifei; Li, Yangyang; Wang, Jun; Dai, Xiaolan; Zeng, Dongping; Xiong, Wenguang; Zeng, Zhenling
- Abstract
Streptococcus suis, an encapsulated zoonotic pathogen, has been reported to cause a variety of infectious diseases, such as meningitis and streptococcal-toxic-shock-like syndrome. Increasing antimicrobial resistance has triggered the need for new treatments. In the present study, we found that isopropoxy benzene guanidine (IBG) significantly attenuated the effects caused by S. suis infection, in vivo and in vitro, by killing S. suis and reducing S. suis pathogenicity. Further studies showed that IBG disrupted the integrity of S. suis cell membranes and increased the permeability of S. suis cell membranes, leading to an imbalance in proton motive force and the accumulation of intracellular ATP. Meanwhile, IBG antagonized the hemolysis activity of suilysin and decreased the expression of Sly gene. In vivo, IBG improved the viability of S. suis SS3-infected mice by reducing tissue bacterial load. In conclusion, IBG is a promising compound for the treatment of S. suis infections, given its antibacterial and anti-hemolysis activity.
- Subjects
STREPTOCOCCUS suis; STREPTOCOCCAL diseases; GUANIDINE; BENZENE; CELL membranes; STREPTOCOCCUS pneumoniae
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 8, p7354
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24087354