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- Title
Bamboo Salt and Triple Therapy Synergistically Inhibit Helicobacter pylori -Induced Gastritis In Vivo: A Preliminary Study.
- Authors
Lee, Tae Ho; Jeong, Hang Yeon; An, Do Yeon; Kim, Haesung; Cho, Jeong-Yong; Hwang, Do Young; Lee, Hyoung Jae; Ham, Kyung-Sik; Moon, Jae-Hak
- Abstract
Helicobacter pylori infections are a major cause of gastrointestinal disorders, including gastric ulcers, gastritis, and gastric cancer. Triple therapy, using two antibiotics and a proton pump inhibitor, is recommended for the treatment of H. pylori infections. However, antibiotic resistance in H. pylori is an emerging issue. Bamboo salt, a traditional Korean salt made by baking solar sea salt in bamboo barrels, can ameliorate the symptoms of various gastrointestinal diseases. Herein, we compared the anti-H. pylori activity of triple therapy (clarithromycin, metronidazole, and omeprazole), solar salt, and bamboo salt in vivo as a preliminary study. Four-week-old C57BL/6 male mice were inoculated for eight weeks with the H. pylori Sydney Strain 1 (SS-1) and orally administered triple therapy drugs and salts for five days. The transcript levels of the H. pylori-expressed gene CagA and inflammatory cytokines Tnfα and Il-1β significantly decreased in the bamboo salt treated mice than those in the H. pylori-infected control group. This effect was further enhanced by using triple therapy and bamboo salt together. Solar salt caused modest inhibition of H. pylori-induced inflammation. We also demonstrated the synergistic effects of bamboo salt and triple therapy against H. pylori. Thus, bamboo salt may be a potential candidate agent against the treatment of H. pylori-associated gastritis.
- Subjects
HALOTHERAPY; HELICOBACTER pylori; HELICOBACTER pylori infections; GASTRITIS; SEA salt; BAMBOO; OMEPRAZOLE
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 22, p13997
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232213997