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- Title
Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota.
- Authors
Liao, Jin-Xian; Chen, Yu-Wei; Shih, Ming-Kuei; Tain, You-Lin; Yeh, Yao-Tsung; Chiu, Min-Hsi; Chang, Sam K. C.; Hou, Chih-Yao; Alpini, Gianfranco
- Abstract
Resveratrol can affect the physiology or biochemistry of offspring in the maternal–fetal animal model. However, it exhibits low bioavailability in humans and animals. Fifteen-week SD pregnant female rats were orally administered bisphenol A (BPA) and/or resveratrol butyrate ester (RBE), and the male offspring rats (n = 4–8 per group) were evaluated. The results show that RBE treatment (BPA + R30) compared with the BPA group can reduce the damage caused by BPA (p < 0.05). RBE enhanced the expression of selected genes and induced extramedullary hematopoiesis and mononuclear cell infiltration. RBE increased the abundance of S24-7 and Adlercreutzia in the intestines of the male offspring rats, as well as the concentrations of short-chain fatty acids (SCFAs) in the feces. RBE also increased the antioxidant capacity of the liver by inducing Nrf2, promoting the expression of HO-1, SOD, and CAT. It also increased the concentration of intestinal SCFAs, enhancing the barrier formed by intestinal cells, thereby preventing BPA-induced metabolic disruption in the male offspring rats, and reduced liver inflammation. This study identified a potential mechanism underlying the protective effects of RBE against the liver damage caused by BPA exposure during the peri-pregnancy period, and the influence of the gut microbiota on the gut–liver axis in the offspring.
- Subjects
GUT microbiome; OXIDANT status; RESVERATROL; SHORT-chain fatty acids; BUTYRATES; HEMATOPOIESIS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 10, p5273
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22105273