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- Title
Mitochondrial Dysfunctions in Type I Endometrial Carcinoma: Exploring Their Role in Oncogenesis and Tumor Progression.
- Authors
Musicco, Clara; Loizzi, Vera; Cicinelli, Ettore; Cormio, Gennaro; Pesce, Vito; Cormio, Antonella; Resta, Leonardo; Ranieri, Girolamo
- Abstract
Type I endometrial cancer (EC) is the most common form of EC, displaying less aggressive behavior than type II. The development of type I endometrial cancer is considered a multistep process, with slow progression from normal endometrium to hyperplasia, the premalignant form, and endometrial cancer as a result of an unopposed estrogenic stimulation. The role of mitochondria in type I EC tumor progression and prognosis is currently emerging. This review aims to explore mitochondrial alterations in this cancer and in endometrial hyperplasia focusing on mitochondrial DNA mutations, respiratory complex I deficiency, and the activation of mitochondrial quality control systems. A deeper understanding of altered mitochondrial pathways in type I EC could provide novel opportunities to discover new diagnostic and prognostic markers as well as potential therapeutic targets.
- Subjects
ENDOMETRIAL cancer; NEOPLASTIC cell transformation; MITOCHONDRIAL proteins; DNA; ADENOSINE triphosphate; CHARTS, diagrams, etc.
- Publication
International Journal of Molecular Sciences, 2018, Vol 19, Issue 7, p2076
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms19072076