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- Title
A novel nanoemulsion based on clove and thyme essential oils: Characterization, antibacterial, antibiofilm and anticancer activities.
- Authors
Hashem, Amr H.; Doghish, Ahmed S.; Ismail, Ahmed; Hassanin, Mahmoud M. H.; Okla, Mohammad K.; Saleh, Ibrahim A.; AbdElgawad, Hamada; Shehabeldine, Amr M.
- Abstract
Background: Essential oil nanoemulsions have received much attention in the last period due to their ability to fight microbes and cancers. In the current study, clove and thyme essential oils CL+THemulsion and CL+TH-nanoemulsion were prepared through an eco-friendly method. The prepared CL +TH-nanoemulsion was characterized using DLS and TEM analyses. Results: Results revealed that CL+TH-nanoemulsion droplets were spherical in shape and nanoform in size (68.6 nm) with PDI 0.281. MIC concentrations of CL+TH-nanoemulsion against tested bacteria were found to be between 6.25 and 25 mg/mL. After being exposed to MICs of CL+TH-emulsion and CL+THnanoemulsion, which additionally prompted 1.43 log and 3.12 log declines, accordingly, as opposed to untreated (Control), the number of cells grown in the generated biofilms decreased. Furthermore, CL +TH-nanoemulsion exhibited anticancer activity more than CL+TH-emulsion toward HepG2 and MCF- 7. Also, the effect of CL+TH-nanoemulsion is more effective and significantly cytotoxic than taxol on MCF-7. Besides, both prepared emulsions increased the rate of apoptosis and decreased the cell viability % of MCF-7 by increasing the activity of caspases 8 and 9. Moreover, CL+TH-nano emulsion decreased the activity of VEGFR-2 in MCF-7 in a more pronounced manner than CL+TH-emulsion and taxol. Conclusions: The prepared CL+TH-nanoemulsion had antibacterial, and antibiofilm as well as anticancer properties, which can be used in different biomedical applications after extensive studies in vivo.
- Subjects
ESSENTIAL oils; THYMES; ANTINEOPLASTIC agents; PACLITAXEL; CELL survival; CASPASES; TERPENES
- Publication
Electronic Journal of Biotechnology, 2024, Vol 68, p20
- ISSN
0717-3458
- Publication type
Article
- DOI
10.1016/j.ejbt.2023.12.001