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- Title
Inhibitory effect of Yukmijihwang-tang, a traditional herbal formula against testosteroneinduced benign prostatic hyperplasia in rats.
- Authors
Shin, In Sik; Lee, Mee Young; Ha, Hye Kung; Seo, Chang Seob; Shin, Hyeun-Kyoo
- Abstract
Background: Yukmijihwang-tang, a traditional herbal formula, has been used for treating disorder, diabetic mellitus and neurosis in China (Liu-wei-di-huang-tang in Chinese), Japan (Lokumijio-to in Japanese) and Korea for many years. In this study, we investigated the effects of Yukmijihwang-tang water extract (YJT) on the development of benign prostatic hyperplasia (BPH) using a rat model of testosterone propionate (TP)-induced BPH. Methods: A total of 30 rats were divided into five groups. One group was used as a control and the other groups received subcutaneous injections of TP for 4 weeks to induce BPH. YJT (200 or 400 mg/kg) was administered daily for 4 weeks to two groups by oral gavage concurrently with the TP. The animals were euthanized, the prostate and body weights were recorded, and tissues were subjected to hormone assays and histomorphology. In addition, we investigated proliferating cell nuclear antigen (PCNA) expression in the prostate using immunoblotting. Results: Animals with BPH showed significantly increased absolute and relative prostate weights, increased dihydrotestosterone levels in the serum or prostate and increased PCNA expression in the prostate; however, YJT-treated animals showed significant reductions compared with the animals with TP-induced BPH. Histomorphology also showed that YJT inhibited TP-induced prostatic hyperplasia. Conclusions: These findings indicate that YJT effectively inhibited the development of BPH and might be a useful drug clinically
- Subjects
ANALYSIS of variance; ANIMAL experimentation; ANTHROPOMETRY; BIOLOGICAL assay; ENZYME-linked immunosorbent assay; HIGH performance liquid chromatography; IMMUNOBLOTTING; BOTANIC medicine; PROSTATE; RATS; RESEARCH funding; STATISTICS; TESTOSTERONE; WESTERN immunoblotting; BENIGN prostatic hyperplasia; DATA analysis; DESCRIPTIVE statistics
- Publication
BMC Complementary & Alternative Medicine, 2012, Vol 12, Issue 1, p48
- ISSN
1472-6882
- Publication type
Article
- DOI
10.1186/1472-6882-12-48