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- Title
Vaccine adjuvants: Tailor-made mast-cell granules.
- Authors
Gunzer, Matthias
- Abstract
The article presents a study that investigates synthetic submicrometre polymer particles consisting of tumor necrosis factor (TNF) entrapped in a matrix of the polyelectrolytes chitosan and heparin. It is mentioned that the synthetic particles replicate the functions of mast-cell granules, including the encapsulation of immunostimulatory mediators. It is suggested to investigate the mechanisms by which the encapsulated cytokines mediate the observed immune responses.
- Subjects
TUMOR necrosis factors; POLYELECTROLYTES; MAST cells; IMMUNOLOGICAL adjuvants; CYTOKINES
- Publication
Nature Materials, 2012, Vol 11, Issue 3, p181
- ISSN
1476-1122
- Publication type
Article
- DOI
10.1038/nmat3257