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- Title
Identification of two novel HLA-DRB1*11 alleles (DRB1*110404 and DRB1*1161) in two Italian cord blood units.
- Authors
Longhi, E.; Frison, S.; Serafini, M.; Karpasitou, K.; Poli, F.
- Abstract
We describe the isolation and characterization of two novel HLA-DRB1*11 alleles, officially named DRB1*1161 and 110404. These two new variants were both identified in two Caucasoid individuals. The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC>AAC) is responsible for an amino-acidic change from Asp to Asn. The exon 2 sequence of the second novel allele described here, DRB1*110404, differs from that of DRB1*110401 only at codon 34 where the nucleotidic change CAA>CAG gives rise to a silent mutation.
- Subjects
CORD blood; EXONS (Genetics); NUCLEOTIDE sequence; GENETIC mutation; CAUCASIAN race; GENETICS
- Publication
International Journal of Immunogenetics, 2007, Vol 34, Issue 4, p237
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/j.1744-313X.2007.00692.x