We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis of Potentially Antioxidant and Antibacterial.
- Authors
1, Ashraf A.; 2, Esam A.; El Malah, Tamer; Brown, Alan B.; Elayat, Wael M.
- Abstract
In 3-5 h at 60-80ºC in pyridine, thiosemicarbazones reacted with 2-arylidenemalononitriles to afford arylidenehydrazono-4-aryl-2,3-dihydrothiazole-5-carbonitriles. On repeating the same reaction in a domestic microwave oven with a few drops of pyridine, the reaction proceeded in 5-10 min to produce the same dihydrothiazole products in nearly quantitative yields. The structures of the products were elucidated via NMR, IR, and mass spectra and elemental analyses. Antibacterial activities (against Gram-positive and Gram-negative bacteria) and antioxidant activities were tested. A thiazolidine having a pyridyl group connected to the azomethine carbon, ( E)-5-phenyl-2-(( E)-(1-(pyridin-2-yl)ethylidene)-hydrazono)-2,3-dihydrothiazole-4-carbonitrile showed high antioxidant and antibacterial activities. A promising antioxidant activity was also noted in the starting thiosemicarbazones. The was investigated.
- Subjects
ANTIOXIDANTS; ANTIBACTERIAL agents; THIOSEMICARBAZONES; CARBONITRILES; PYRIDINE
- Publication
Journal of Heterocyclic Chemistry, 2015, Vol 52, Issue 6, p1758
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.2248