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- Title
Protective effect of rutin on cognitive impairment caused by phenytoin.
- Authors
Dubey, Shagun; Ganeshpurkar, Aditya; Bansal, Divya; Dubey, Nazneen
- Abstract
Objective: To study the effect of the co-administration of phenytoin (PHT) and rutin in comparison with PHT and piracetam (PIM) on seizure control, cognitive, and motor functions in mice. Materials and Methods: Increasing current electroshock seizure (ICES) test was used to evaluate the effect of the co-administration of PHT and PIM on convulsions. Cognitive functions in mice were assessed by a spontaneous alternation in behavior on a plus maze while motor functions were screened using rolling roller apparatus and by counting the number of arms entries on a plus maze. Brain acetyl-cholinesterase (AChE) activity was also estimated. Statistical Analysis: The expression of data was done as mean - standard error of the mean. The normally distributed data were subjected to one-way ANOVA followed by Dunnett's test. P < 0.05 was considered significant. Results: The study showed that rutin when co-administered with PHT, significantly reversed PHT-induced reduction in spontaneous alternation without altering the efficacy of PHT against ICES, in both acute and chronic studies. Further, it also reversed PHT-induced increase in AChE activity. Conclusion: Rutin alleviated the PHT-induced cognitive impairment without compromising its antiepileptic efficacy.
- Subjects
PHENYTOIN; RUTIN; PIRACETAM; SEIZURES (Medicine); ACETYLCHOLINESTERASE
- Publication
Indian Journal of Pharmacology, 2015, Vol 47, Issue 6, p627
- ISSN
0253-7613
- Publication type
Article
- DOI
10.4103/0253-7613.169581